The wide split is great for shoulders and the shortcut panel helps with cutting down on common multi-key movements (copy, paste, etc).
The Pro steps up from the other Freestyles with mechanical keys and programmability. I'm using the programmability to remap some of the modifier keys for comfort. Combined with the panel of common shortcuts, it's much easier on my hands.
A bonus of having a programmable keyboard is that you don't need to rebind keys in the OS, something that's not always possible to do in corporate environments.
