If I could get something that could measure exact interaction response times of synapses then perhaps that might be a starting point. The equipment exists but doubt I could even afford the grey-market gear nor do I have a place to put it.
One might ask why I take these molecules if I can not measure efficacy. For me it's simple. They are relatively cheap and there are enough studied benefits that even if the gains are marginal I will find that an acceptable net gain in the big picture of my overall health.
I got some Lion's Mane capsules from Amazon (though I'm not sure how pure they are; for all I know they crushed up some whitecaps and put those in there). I started with 1/3 the recommended daily dose and started having slight headaches. That was the end of that experiment. :-(
Don't get me wrong, if you feel like it helps you then go for it, but objective claims deserve objective evidence.
Specifically, erinacines and hericenones.