At least pointing devices come in different shapes and forms, including vertical and trackballs. We used to enable chrome accessibility feature [1] to automatically drag-click when the mouse button is stopped. Although, as kids got faster they turned it off. It's a nice option to have.

[1]https://mcmw.abilitynet.org.uk/how-to-make-your-mouse-click-...

One of the reasons why we made auto-clicking mouse is so, when playing games, they don't have to click it crazy fast (besides it being fun project). To increase keyboard ergonomics I am thinking on a custom keyboard with programmable keys to, for example to turn long-press space into backspace, shift space to enter.