A moon base with a 3 day turnaround and dedicated return hardware would be pretty safe relatively speaking. The moon doesn't really DO much. The weather is 100% predictable since there is no atmosphere. Seismic activity is nil. Asteroid and debris impacts are much rarer than in LEO. In addition you have plenty of moon soil for burying inflatable structures.
You would absolutely NEED nuclear or hydrogen fuel cells since nights are 2 weeks long. Life support is easier than in orbit because you have a giant mass of moon to cool the air in your habitat instead of needing an ammonia based heat pump.
Economically speaking, if Starship performs as advertised at $20/kg to LEO, it is totally doable. They are talking about $2 million per launch. To put it into perspective, a chartered 747 costs about $30k per hour. A ten hour flight in a 747 costs about 1/6 of a Starship flight to orbit. When they say "Game Changer" they aren't just blowing smoke.
Also, there's just no reason to put people on the moon, why would somebody spend the money to do that?
