This isn't just slightly slower, it depends a lot on your data how slow this is. It's potentially linear in the length of single-column matches. E.g. a query plan for (region='us' AND product='1234' AND year='2021') could scan the region index for all 'us' tuples, the product index for all '1234' tuples, and the year index for all '2021' tuples. The result might only be 0.0001% of rows, but this might have to scan more index entries than you have rows in the database. In some cases it's probably better to use one index and apply the remaining column filters as you fetch rows from the heap.
If you don't care about performance or only have a few MB of data then maybe you will get away with it, but I've never worked on a project where database performance wasn't an issue.