S0ix has stronger requirements on the "correct" interaction between firmware/BIOS and OS, it offloads more work to the OS. Poorly implemented S0ix will drain the battery faster, but correctly implemented S0ix is as good as S3 or even better.
Lenovo put out a buggy S3 implementation on some systems that hasn't been tested well because it's only an optional "Linux suspend" setting. Drains twice as fast as Linux with correctly implemented S0ix. And the worst thing is, nobody except Lenovo do can fix it because it's all on the BIOS level, and their China-based firmware team has other priorities.
Well-implemented S3 is nice. But it's going to disappear. Both Intel and AMD are switching away with full force, vendors won't have S3 options in the BIOS going forward and the ones that remain will likely suck. On the other hand, S0ix support is coming together even on AMD platforms which were a little late to the party. Once it's working decently, I'd rather trust my OS than my laptop manufacturer's firmware team to suspend components correctly.