I must have not done a good job explaining.
Of course depression is a biological condition (because the mind emerges from the brain). That doesn't mean it's a
single condition with a
single cause or even a group of
pathological causes, the way cancer is, or MLS.
But yes, of course it's biological. What an intellectually honest psychiatrist would say is something like "look, you're not doing well. Here are some things we can try to shift the playing field a bit. We don't know exactly how they work or why, but we know they do work, somewhat. Want to try? Here's the side effects: "
That would be intellectually honest. Saying "you have A (single, diagnosed) disease, caused by "a chemical imbalance", and the root cause of that disease is treated by this medicine" is dishonest.