On a flat keyboard, hitting that top row (especially edge keys like the 5 and 6) required either moving my entire hand or doing some weird reaching motion. And I wear a 4XL glove so I don't even know how other people deal with the top row at all. Being able to not move your hands as much doesn't sound like a big thing but it helped a lot with my wrist issues because I can find a comfortable position when I get started and never leave it until I stand up.
I'm currently on a scooped and fully split KB from bastardkb.com which is kind of the best of both worlds (scooped for reach, split for my shoulders, and custom firmware so I can use less keys overall). But if Kinesis offers that out-of-the-box it's a pretty easy choice for my next keyboard.
- QMK is second to none. With the moonlander specifically I can flash my keyboard from any OS with nothing but a browser and a paperclip.
- Tenting is easy, adjustable, and feels good to use. I liked the thumb cluster tenting (over the ergodox) because it felt more natural.
- Excellent build quality, wrist rests are comfy, and it's pretty portable (it's in my carryon bag right now).
- High quality switch and cap choices (mostly, the custom thumb buttons are obviously nonstandard. But I strongly disliked the rubber function key row of the advantage 2)
- I occasionally play FPS games, and like that I can disconnect the right half of the keyboard and gain more mousepad real estate.
Kinesis pros:
- Mainly the shape. I think the kinesis is probably the most natural device to type on. The moonlander is comfy, but I think the kinesis is still more natural overall. The sculpted key-well is ideal, IMHO.
Both keyboards have eliminated my carpal tunnel symptoms, so I don't have any issues recommending either. If you're going to travel with a keyboard, definitely get the moonlander. But I think from a pure ergonomic standpoint - the kinesis wins.
If I ever switch jobs and have a keyboard stipend, I'll purchase the Advantage 360 and write a full review. But I'm very happy with my present position :)