Same experience here with 15 years of Arch usage, a few major issues before systemd, none since, except having to migrate the boot loader, network manager and so on to systemd and from time to time having to use a workaround from the latest news at archlinux.org. I have also migrated to pipewire a month ago with a single command and no issues.
It's quite stress free, because the whole operating system is basically the kernel, systemd, x11 or wayland, pulseaudio or pipewire, the nvidia driver and pacman. Not much can go wrong.