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When you're owned by Amazon you don't need to optimize too much to achieve web scale... just leverage AWS services. It's not like you're going to get a bill.Oh you're be surprised. Divisions get billed constantly for the AWS resources they consume, and this bill gets taken out of their annual budget. From what I hear, this is a common practice in most large organizations.
Also, the AWS services you can access from within Amazon are almost identical to the AWS services you can access as an external customer. It's equally easy/hard for a random company to achieve web scale, compared to Twitch.