I don't think this is true. Even without underlines, which are common in notes, people place their notes based on a combination of the layout of the page and their personal preferences. I don't think it's possible to know, given one layout and note placement, how to place the note in a new layout.
It is also worth saying that many historic uses of marginalia (for example, commentary on the Tanakh) are also associated with particular parts of the text and could not be laid out as you are describing without losing intended meaning.