We're evaluating this product to replace our self-hosted "resize and deliver images on the Internet" solution and we definitely do have source images over 10mb. I'm not worried about the migration, but this means that going forward we might need our app (or worse our users) have to resize images down before uploading them to the image resizing service. That's a bummer.
EDIT: I just checked, 2.5% of source images are over 10mb.
An easy solution might be to have it accept an upload of a larger file, but automatically scale it down to fit under 10mb and then only store that as the new original.