Being a good driver does a ton to insulate you from the shenanigans of
Equipment failure is basically a rounding errors but also within the driver's control since "flat tire at speed" is probably lion's share of crashes in that category.
One thing that's different between GA and driving is that you could stop driving. An hour from home, realising that the road really is too treacherous, you could pull over and walk. Up in the sky they don't have that option at a moment's notice. But one thing that's exactly the same is mission mindset - people fixate on what they intended to do until after it's far too late rather than have contingency plans.
This isn't a problem in airline flights. There are very specific rules about when you can and cannot depart and when an alternate airport and fuel for it is required. No airline takes off without satisfying all the rules and almost no airline cancels a flight for weather while the rules say it could go.