You're going to get some number of people against anything. 96% of doctors were fully vaccinated by June [1], for example. Does the 4% holdout actually worry anyone? It shouldn't.

You also have to double check beyond headlines. For example, I saw people talking about how the FDA EUA panel wasn't a consensus for Pfizer 16+ back in the day. Turns out, most of the people who were hesitant just wanted to start with 18+, not 16+. That's a huge difference from what some of the headlines were saying.

[1] https://www.ama-assn.org/press-center/press-releases/ama-sur...

Yes this is a great point. The primary concerns & warnings are generally around vaccine induced immune escape, which is a realistic consequence of indiscriminate compulsory mass vaccination [1][2][3][4][5][6].

That said, there is general consensus in the literature that the vaccines are mostly safe for adults in the short term. However for certain sub-populations (eg pediatrics and pregnant women) there isn't enough evidence yet from clinical trials and longitudinal studies to conclude with certainty that the benefits of compulsory mass vaccination outweigh the risks.

[1] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein https://pubmed.ncbi.nlm.nih.gov/33909660/

[2] Can we predict the limits of SARS-CoV-2 variants and their phenotypic consequences? https://www.gov.uk/government/publications/long-term-evoluti...

[3] Why does drug resistance readily evolve but vaccine resistance does not? https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2016...

[4] The adaptive evolution of virulence: a review of theoretical predictions and empirical tests https://pubmed.ncbi.nlm.nih.gov/26302775/

[5] Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens https://journals.plos.org/plosbiology/article?id=10.1371%2Fj...

[6] Necessity of COVID-19 vaccination in previously infected individuals https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...