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0 pointsanonuser1234564y ago0 comments

Another issue is, other targets may not provide neutralizing immunity and may facilitate ADE. I don't think we've seen ADE in natural infection yet, so it may just be a theoretical issue, but I also don't know if we've really looked for ADE in natural infection either.

We do know that other similar coronavirus vaccine candidates (a candidate for SARS-COV-1) exhibited ADE in primate studies. So since the spike protein appears effective currently, maybe it's best to stick with that.

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raphlinus4y ago· 1 in thread

For people curious about ADE (a fascinating topic that so far doesn't seem to have caused problems with SARS-CoV-2), here is some excellent background reading that covers many of the points made in the above comment, with citations and deeper discussion:

https://blogs.sciencemag.org/pipeline/archives/2021/02/12/an...

anonuser123456OP4y ago

I remember when this whole thing originally broke out, ADE was my biggest fear. Even when China was talking about a 2-3% infection fatality rate, it's like ok.. well that's not going to shatter society. But ADE... the prospect that getting it a 2nd time would raise the IFR to who knows... 20+%? That was scary.

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