You know that situation where you're out to brunch at a popular spot, there are 10 people on the list, maybe it's raining. Everyone's crowding inside, you try to stand in one spot but it is blocking the list, you try another spot but the waitress wants by, you try a third and now you're blocking the door. That's how I feel about SF all day every day. There's no space for me. Street cleaning: move the car, traffic: people won't let you merge, Dinner: "it'll be a 45 minute wait" that's fine, I'll go to the bookstore. "oh we called you 20 minutes early (why weren't you here?)" So now you lost your table. (this happened to me last night). What else... parking is a nightmare, the bus is full of vomit and shit, don't walk down mission street in Soma (oh you work there? be sure to step over the needles and human feces). And the subway only goes one place. And the day a cracked out homeless guy tries to sell you a lego set is the highlight of the year because at least it wasn't drugs.
You can avoid those areas, but I was just driving some out of town friends to their hotel on Nob Hill and Robin says to me, "I think that guy's pants are entirely off." I see people with their pants down basically every time I go out. It's fine, I don't really care, but I haven't stepped in this much human excrement since I wandered around the slums of Mumbai and it starts to wear on you.