No one thought that Go was impossible except people who weren't involved in engineering/software and shouldn't have been taken seriously in the first place.

Superhuman game AI has existed for decades. It's entirely unsurprising that one can play a strategy game, and no one thought it wasn't possible.

I'll send you $500 USD if AlphaFold derivatives lead to a single new therapy or drug that helps real patients in the next 5 years.

DM didn't "solve" anything around proteins. They just made an improvement to existing homology modelling methods. If you look, the system is incredibly dependent on having large numbers of high quality sequence alignments to proteins with known structure and lots and lots of evolutionary data.

This was actually fairly obvious 20 years ago and it's been disappointing to me to see how long it took somebody to make this improvement, but really, it couldn't have been done without recent algorithmic improvements and huge amounts of CPU time.