I'd worry about a POST route that does some expensive/slow reads/computations in the first half of the request, and then only writes at the end – lots of lost time! Would have been much better to say, hey, for this route (or for any POST route in _my_ application), please bounce to the region with the primary db instance.
Actually, while that could be done at the application level with reasonable latency, it'd probably still be better to allow the user to write some rules at the proxy layer for the "first guess".