This was addressed in my previous comment. I've known folks who took the stuff and had a horrible reaction, without family history as such.

Also, consuming street drugs of unknown quality in uncontrolled settings with uncontrolled dosages is quite different than controlled medical experiments.

> overblown

I never wanted to try the stuff after personally observing people change after having a "bad trip". If it permanently alters perceptions in unpredictable ways, then ingesting it likely catalyzes alternate life trajectories, also in unpredictable ways.

Seems like a double edged sword. Many report the positive benefits but the supporters seem to downplay risks or point to other factors without supporting evidence.

It's unclear how to determine safety with prospective victims/winners whose family history doesn't include mental illness. Again, I suspect dosage is a critical factor to trip outcome; this being common pharmacological wisdom.