This happens a lot for third declension nouns where nominative ends in -s (opus is one such example)
Other examples of this pattern:
Corpus -> corporem (not *corpusem)
Venus -> Venerem (not *Venusem)
Flos -> florem (not *flosem)
Colos -> colorem (not *colosem)
Or more simply, we can look at opus and see it comes from a different PIE root from cyber. (When i look it up, the former has a root meaning "work", and the latter has a root meaning "turn")