This, for me, certainly drove home how much I hate refactoring things. If I need to reconfigure my factory for some reason, beyond throwing in a little spaghetti and in-filling some gaps to add another few bits of production, I'll just waltz off into the distance a ways and start anew, piping in resources from the old factory as needed.
And then I run into bottlenecks arising from the utilization of the old factory and the process repeats itself.