I'm 100% on board with not using 1P's TOTP for guarding the AWS Master Payer Account for my company, but my GitHub account is not a nation state threat, so having 1P autofill the code after it autofills the long password is very convenient
I have also experimented with passwords in one manager, TOTP in another, but ... as I said about that convenience spectrum
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Kind of related to that last item, I also have gotten a lot of mileage out of KeePassXC's autotype feature for having it type my GPG pass phrase into pinentry. It stays out of the clipboard, I only have in use it within the pinentry timeout, and it's convenient. I wish 1P had similar behavior on sane OSes (1P will autotype into certain fields on Windows 10 but that convenience extends only to my gaming accounts because I'm not going to use Windows)