You probably
can do it, but should you? You can build a house using only cardboard, or write a book using only words shorter than six letters. The result is not simplicity, though. The result is an idiosyncratic oddity that will have you swimming upstream, something no one else can understand, with huge usability and interoperability problems.
You can’t get around the unfortunate fact that web browsers only render HTML, CSS, and Javascript. Yes, the front-end landscape is a complicated mess, and it takes time to learn. Many frameworks and libraries exist to abstract and hide a lot of the mess — take your pick. Eventually you either understand and can work with HTML, CSS, and JS or you don’t. If you don’t you will limit what you can accomplish, and your job prospects.