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0 pointsjcims5y ago0 comments

Sure but they are still made of amino acids and presumably could be translated from some sequence of mRNA. You might need to modify it slightly to provoke the alternate folding while still maintaining the essential infectious/auto-catalyzing structure.

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sterlind5y ago· 2 in thread

...and that's why I've been terrified of bioterrorism. your plan is simple and elegant and horrifying. making such viruses is getting easier every day. eventually it will be easy enough that some crank will do something like this. Jesus..

we should increase funding for developing pathogen sensors, and put them in public transportation hubs. eventually we'll probably start requiring saliva or nasal swabs from randomly-selected travelers. it sucks but I don't see a better way..

jcimsOP5y ago

For anyone that isn’t aware: https://www.genscript.com/crispr-services.html

Gene-mods-R-Us! lol

Especially now that we can actually image individual proteins to help discover their structure: https://www.pnas.org/content/114/7/1474

I’m sure there are complications that make this much more difficult than it seems on the surface, but we should probably get that Mars thing going just in case haha.

OnlyANeurosci5y ago

Yeah, genetic constructs often don't work well even when you plan for them to work and are doing something "easy". It's not uncommon to have to try 10-30+ variations of adding a His-Tag to a protein (for purifying a protein product like say, insulin). There isn't a ton known about how prions are formed initially, which would be critical to designing one.

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