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0 pointsherenow20215y ago0 comments

My understanding is that even if the drug is available in Brazil OTC it has become politicized, so it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care?

Ivermectin is incredibly safe. "Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year." https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.20...

"Hepatic adverse events Ivermectin was suspected to be a hepatotoxicant. In fact, this claim reproduced in several publications was based on few individual case reports [Sparsa, 2006; Veit et al., 2006; Hirota et al., 2011] where the causal relationship with ivermectin treatment was not convincingly established. The last update of LiverTox [2018], a database of drug-induced hepatotoxicity, did not classify ivermectin as a known hepatotoxicant, a conclusion recently confirmed by the US National Institutes of Health [NIH, 2021]."

Taken from a recent 48 page review of the the entire literature on Ivermectin safety by a medical toxicologist: https://www.medincell.com/wp-content/uploads/2021/03/Clinica...

(edit: not 50,000 liver failures, 56,000 er room visits :)

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raverbashing5y ago· 1 in thread

> it's not considered standard of care. Do you have any links where health authorities in Brazil have made it standard of care?

"Nobody cares" about standard of care. The medical college (CRM) has pretty much said that the doctors are free to prescribe whatever they want

> Ivermectin is incredibly safe.

Yes, at the recommended doses for parasite control (which is a single or dual dose), not for usage for several consecutive days or weeks (and I agree with the Paracetamol criticism)

amnot_billgates5y ago

Anti-depressants are approved after a few weeks of study, and people use them for years without safety concerns. People have taking 10 times the dose of regular ivermectin without harm (https://pubmed.ncbi.nlm.nih.gov/12362927/). I guess we are in slightly uncharted waters with ivermectin, but there is no evidence from the people who chronically prophylax for covid that regular dosing has caused them issues.

And ivermectin is safest of the current covid treatments, so I find it hard to accept that we shouldn't use it because of safety concerns (for comparison, since 1992 the pharmocavigilance database shows less than 1 death per year from ivermectin, where Remdesivir has 500+ deaths, vaccines has over 2000 deaths with only months of usage).

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