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0 pointssimple_phrases5y ago0 comments

Gene therapy and mRNA vaccines are two very different things.

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4 comments · 2 top-level

kaczordon5y ago· 2 in thread

True corrected it to “gene-based”, both jnj and astra use DNA encoding btw.

But neither have the ability to alter your DNA, so they are unlikely to be able to cause long-term symptoms though a gene-expression mechanism.

kaczordon5y ago

Right but they are still gene-based. No gene-based vaccine has ever received approval for human use, and the present coronavirus vaccines have not undergone preclinical testing as normally required by international regulations.

A potential danger of DNA-based vaccines is the integration of plasmid DNA into the cell genome (1). Insertional mutagenesis occurs rarely but can become a realistic danger when the number of events is very large, i.e. as in mass vaccination of a population.

(1) https://www.nature.com/articles/3302213

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amalcon5y ago

This is the J&J vaccine, which is not mRNA-based. It's an adenovirus vector vaccine, which is also not gene therapy but is a (tiny) bit closer than an mRNA vaccine.

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