Main benefit for me is that I don't need to remember how to write css. 95% of what I need is a shortcut away from tailwind docs. The result is "prettier" than any other website-from-scratch I've done (that's purely on me, not much css practice). Now that I've memorised most common tailwind classes, I'm also moving faster than ever.
Main downside is that it's annoying having to modify tailwind's config file to add non-default variations (mostly different heights/widths than what it ships with).
Maybe something like Girouette[0] would be better.