I take it you meant to say "VMS" here, not VAX.
I don't think the size of a system is essential to whether it counts as "UNIX" or not. The normal trajectory of any system which starts small is to progressively grow bigger, as demands and use cases and person-years invested all accumulate. UNIX has followed exactly that trajectory. I don't see why if a small system gradually grows bigger it at some point stops being itself.
I think there are three main senses of UNIX – "trademark UNIX" (passing the conformance test suite and licensing the trademark from the Open Group), "heritage/genealogical UNIX" (being descended from the original Bell Labs Unix code base), "Unix-like" (systems like Linux which don't descend from Bell Labs code and, with rare exception, don't formally pass the test suite and license the trademark, but which still aim at a very high degree of Unix compatibility). I think all three senses are valid, and I don't think size or scale is an essential component of any of them.
UNIX began life on small machines (PDP-7 then PDP-11), but was before long ported to some very large ones (for their day) – such as IBM mainframes – and the operating system tends to grow to match the scale of the environment it is running in. AT&T's early 1980s IBM mainframe port [0] was noticeably complicated, being written as a layer on top of the pre-existing (and obscure) IBM mainframe operating system TSS/370. If being small is essential to being UNIX, UNIX was only a little more than 10 years old before it was already starting to grow out of being itself.
[0] https://www.bell-labs.com/usr/dmr/www/otherports/ibm.pdf