Not that I can think of, but obviously it depends on what your blocks are doing. I remember having trouble with the backlight block, but I fixed that upstream a long time ago, so it should not be a problem for you anymore.

For reference, my config is at: https://github.com/majewsky/devenv/tree/master/i3status-rust (as a bunch of single-purpose snippets, the actual config file is obtained by concatenating `common/.toml` and `$HOSTNAME/.toml`)