Efforts work best when they are focused on
cost-effective interventions, not things you have direct experience with.
Just about 100% of the US population have no experience with malaria. Yet it costs about $2 to provide a insecticide-treated net that protects on average 2 people for 2-3 years from malaria (while they sleep -- a common time for malaria transmission). There is arguably nothing you can do with $2 of resources in the US that can do as much good as this.
So, please focus on cost-effective charities with a proven track record, that use evidence-based methods to help individuals, and do it in a transparent way (so you know what's happening when you donate). To make it easier, start with GiveWell - an independent charity evaluator: https://www.givewell.org/charities/top-charities