I've had a lot of conversations with javascript engineers over the years who've argued to me that well tuned JS will be nearly as fast as the equivalent C code. I've written plenty of little toy benchmarks over the years, and in my experience they're partly right. Well written JS code in V8 can certainly run fast - sometimes around half the speed of C code. But a massive performance gap opens up when you use nontrivial data structures. Nested fields, non-uniform arrays, trees, and so on will all cripple javascript's performance when compared to C's equivalent of simple embedded nested structs. If you couple clean C data structures with allocation-free hot paths from arenas, the performance of C will easily hit 10-20x the performance of the equivalent JS code.
From memory my plain text based operational transform code does ~800k transforms / second in javascript. The equivalent C code does 20M/second. The C implementation is about twice as many lines of code as the JS version though.
(The code in question: https://github.com/ottypes/text-unicode/blob/master/lib/type... / https://github.com/ottypes/libot )