The book "The Trap: selling out to stay afloat in winner-take-all America" discusses the effect of healthcare on entrepreneurship:[1]

> It's a truism that American culture celebrates entrepreneurs. The opinion polls show exactly what you expect: Americans are incredibly entrepreneurship-minded. A 2005 survey showed that 28 percent of Americans have considered setting up their own businesses, compared to only 15 percent of Europeans. Yet the employment statistics reveal that Americans are far less likely to actually do it — 14.7 percent of the European workforce is self-employed, compared with only 7.3 percent of Americans. American entrepreneurs are clearly being held back from pursuing their dreams. > ... > What explains the paradox? In Europe working for yourself doesn't affect your health-care coverage...In America, the ambitious many are held back.

[1] https://archive.org/details/trapsellingoutto00broo/page/108/...