It gets around a half-million downloads per week according to NPM stats while hyperapp gets under 3k per week.
But looking at the repo https://github.com/hyperhype/hyperscript I have a hard time imagining how preact can work together. They seem to overlap in functionality.
https://preactjs.com/guide/v10/tutorial/
or you can use the full hyperscript markup library
https://github.com/queckezz/preact-hyperscript