A lot of car fatalities are accidents that don't involve alcohol - around 70%.
One time I lost control of my car while driving on the highway and hitting a patch of black ice. Luckily, nobody died. But that happens all the time.
Presumably, a self-driving car will drive slower in adverse weather than a human might, as well as being able to control the car if it hits an ice patch better than an untrained human can.
Also, the car can notify other cars on the same road of the ice patch, instantaneously.