I've recently switched to macOS and Safari with Wipr. I don't see much difference to my Firefox setup with AdNauseam (uBlock Origin) before. More on the contrary - my selected lists were very aggressive and I had various sites where I had to disable uBlock to see them properly. With Safari and Wipr, everything seems to just work.
As a direct fork, it’s currently 2282 commits ahead, 586 commits behind your uBlock. That amounts to about the commits since uBlock 1.29.0 - which is exactly the version they’re claiming to use.