Typically: in the case of a liquidity event or if there is a termination without cause in order to gain control of the co-founders shares. Those terms are pretty common, and without having seen the vesting agreement we shouldn't make any guesses as to what is in there. Leaving can be many things, and co-founders typically don't have the authority to fire each other at will without grave consequences.
FWIW that's only true if he was being paid at least minimum wage. Otherwise he would be entitled to some equity even if he didn't hit his cliff.
Of course, I've since learned that pretty much _anything_ can be re-worked in an M&A agreement -- "we're not buying you without striking this clause" -- so it's no silver bullet.