You can do anything with any language/technology, it's just a question of how many resources you are willing to dedicate to the task. In my case, as a solo bootstrapper, the resources are very limited.

Main advantages:

* a single language for both client-side (browser) code and server-side code

* a single data representation (maps with namespace-qualified keys), so no conversions necessary

* spec which helps validate data in multiple places (such as :pre/:post conditions)

* core.async which lets me write asynchronous code both in the JVM and in the browser, same primitives

* a library of excellent sequence manipulation functions

* transducers, which let me build composable data pipelines

* the Rum library which lets me use React as a rendering engine, basically a function of my data

* most of my domain code is shared between the browser and the server

There is more, but these were what I could come up with immediately.

I mostly spend time thinking and working on the problem domain, not writing boilerplate (there is none in Clojure, really).