I've tried looking a bit into this at one point and my understanding is that it's more a toolkit issue than an app issue.

QT has an option to adapt the size of the widgets according to the reported screen resolution, which seems to kind of work. I don't use that many QT apps, so not sure how this turns out in practice.

However, GTK just doesn't care.

All this is on X11, I hear the situation is somewhat better on Wayland.