Hmm, fwiw I think all my boxes with NoMachine have GPUs as well, that may make a difference in the quality for encoding/decoding.
If I go full screen it's hard for me to distinguish local vs remote, even watching videos, other than occasionally can see video compression artifacts per the connection quality.
Do like that I can blank screen on login, lock screen on logout, similar to RDP, unlike xrdp and others where it's a new session when you connect, you can't resume a session locally (e.g. work half in office, half at home, same session).