PowerPC AS only requires 1 tag bit for every 16 bytes. (1 tag bit for every 128 data bits, 1 tag byte for every 128 data bytes, etc.) That's 8MB of tags for every 1GB of memory. So the overhead isn't massive [1].
Do recent IBM i versions still rely on hardware enforcement of tagged memory?
Even if QEMU does support odd-sized virtual sectors, given the integral support for logical partitioning included within modern IBM i releases, various system management and RAS features, etc., I'd be entirely unsurprised to learn that significant firmware support isn't also required to boot the OS at all, regardless of I/O device support.
In which case, you'd either need to reimplement a significant bit of IBM firmware functionality from scratch, or else you'd need to emulate POWER system hardware convincingly enough to fool (possibly hacked) authentic IBM firmware.
Finally, given that AFAIK IBM has never sold unbundled licenses for IBM i (or OS/400), the only potentially legal way to do any of this would be to run QEMU a POWER system already licensed to run IBM i (no technical problem, as all recent POWER systems have excellent Linux support).
*Where, by "similar", I'm thinking of virtual disks used by virtual instances running within an existing IBM i instance, which wouldn't be helpful here.