The address for friends and family should be split in 2 - one for the really technologically literate ones, who will never do stupid crap with it like using it in a pinterest "Share this!" form, and one for everyone else (who must never learn you didn't give them "best" address because they're clueless).

Also, if you own a few domains, devote a whole cheap one to mailing lists, online subscription and whatever else. Create a dedicated address everytime you subscribe to a service (like mybank@myjunkmaildomain.icu, amazon@myjunkmaildomain.icu, facebook@myjunkmaildomain.icu, somedodgyonlinemerchant@myjunkmaildomain.icu etc).

This gives you the benefit of seeing who leaked your address when you see spam, of being able to disable them individually, of being able to migrate provider with no impact to your accounts (just repoint your own domain's email forwardings)

It makes certain things more complicated, like authenticating against certain services, or if someone sends and invitation to one of your domain emails, but it works just fine 95% of the time.

It works until someone sends an email with cat photos to your secret address and all their contact list, and forget to use bcc.

Also filter all emails with unsubscribe in their body to that folder. Works like a charm.