I bought an xbox and a game for it at the same time from amazon. The xbox was fine the game disk was defective. I contacted amazon via my account, got a call from a human in less than a half hour (mainly I'd say to confirm the xbox itself was OK), received the new game a couple of days later and a refund of my return costs for the game itself.
The only (very) slight quibble I'd have was that the postage on the return exceeded what they refunded. They made the return process itself simple by emailing me barcoded return labels and frequent reminders. I feel very confident buying off amazon a lot more so than ebay for example