Commercial TVs aimed at the digital signage market 
    are an alternative option to a large monitor, 
    especially at larger sizes

I've seen it mentioned that they tend to lack features like HDR and may not have remote controls. Any other downsides?

I would be fine with the lack of a remote, and probably even HDR. I would also be willing to pay a bit of a premium over consumer TVs.

However, information on these displays is pretty tough to come by. I browse home theater type forums/subreddits from time to time and don't see people really talking about using them in the home.