Previously I was used to typing some of the letters on the edges with the "wrong" hand (e.g. typing Y with my left hand) so I mapped an Y onto both halves, but eventually I got rid of that mapping.
I also had to gradually make many other small adjustments to the layout (which is thankfully really easy), because while you can adapt to typing of the letters fairly quickly, keyboard shortcuts and function keys are another matter (especially if you were used to using the function key row with Ctrl/Alt/Shift modifiers).
Having your arms naturally apart is pretty comfortable though, and I also like how cool it looks with the blank keycaps and the metal legs.
If anything, I had bigger issues with a MacBook keyboard, due to the missing Home/End keys, which I use all the time for selecting code (e.g End followed by a Shift+Home or vice versa to select a row, or using Shift+PageUp/PageDown plus arrows to select a block, are very ingrained in my muscle memory).
