I think I saw that implied unexpected twist in NEO-Scavenger, actually. There are newspaper headlines from before the collapse (which was related to a supernatural force of belief being real causing fears to manifest). They mentioned a Chinese Supersoldier Rebellion that had overthrown their government creators, I guess paired hyperintelligence and courage are the last things you want in a populace as an oligarchy or dictatorship as they will see things going wrong and won't be afraid to risk their lives righting it effectively.

It's already been done in China.[1] That was an attempt to produce HIV immunity. Not clear if it worked, but it was done. The Master Race is a ways off, but they're starting from a population with an average IQ of 105, so they're already ahead.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724388/

so basically mutations would be introduced to humankind, not randomly but based X number of ideas controlled by a government and by this removing entropy to our genetic pool.

Virus would love that, yes why no, lets remove the only thing that has keep all living organism on this planet for billions of years from extinction.