Do you think the price-it-yourself model Radiohead used could work for other bands? Radiohead was already huge, thanks to the labels promoting their previous work.
I don't mean to undermine the efforts of last.fm. I just wantto point out how sensational the post's title is.
And while distribution, marketing, recording, etc are certainly all important they can be obtained through other methods without giving up 90% of your earnings. For more information see here: http://news.ycombinator.com/item?id=226352
Pandora is pretty good with recommendations, but doesn't include all the "long tail" bands. Something is missing...all of this needs to be integrated somehow.
People seem to think labels are pointless with the internet now, but without a respected label backing you, good luck getting into a real music festival, good luck getting attention from pitchfork, tv shows, magazines, etc, and good luck getting to tour with other good bands.
MySpace will only get you so far.