undefined | Better HN

0 pointsvikramkr5y ago0 comments

Camelid nanobodies aren't that new, but this is still overselling stuff. I don't like reporting on preprint in general, and this article really doesn't explain the complexities of actually getting some early stage technology like this approved and developed. That's where you end up with the constant barrage of "oh look, another biomedical technology we'll never hear about again" comments, and the amount that this article tries to sell the tech in the headline and article really overstated the readiness of the tech and the near term impact it could have

0 comments

derefr5y ago

If you take it as science reporting, mainly intended to be of interest to scientists or to people who follow the progress of science, then it's sensible. It's similar to the materials-science reporting they do for battery technologies.

These releases coming from University PR departments (this one's from UCSF) aren't really supposed to make it into newspapers for wide consumption. Their target audience is:

1. the people working in the same field—in other Universities, or in industry—who maybe don't have time to read journals, so you've gotta get their attention actively with a "billboard" announcement, rather than putting it in a journal they have to explicitly decide to read;

2. the people who fund the university, who want to see what sorts of neat things their money is being spent on.

Pop-science journalists sometimes glom onto these releases and make them more than they are, "retargeting" them for public consumption. You can certainly object to that. But as originally delivered, these publications are blameless for that.

fabian2k5y ago

I've never seen any scientists reading press releases instead of papers, they are certainly not targeted towards scientists. And you also don't have to read a full journal to notice an individual paper, it's quite common to have keyword-based alerts on Pubmed or something like that.

The level of detail in a press release makes it usually pretty useless to a scientist, it hides the important details behind language intended for non-scientists. The abstract of a paper is much more useful if you need to decide whether it is of interest for you at all.

jrumbut5y ago

I think you're right that the UCSF public relations team is doing neither hard hitting investigative journalism nor the sort of critical pre-Phase 1 analysis that prevents wasted effort in medical device development.

I enjoyed hearing about this new approach to infection control that is its infancy regardless. I felt a little hope for a creative solution to our current crisis and I didn't have to wade through the literature on camelid antibodies to do it.

New technology has always relied on a certain underlying optimism that you can do something that's new and better against the odds (since most fail).

Would you like this better if there was a disclaimer explaining in vitro/in vivo or just the long road from basic research to wide spread deployment?

1 more reply

Duller-Finite5y ago

The article reports on the in vitro results and says they're going to be doing further validation in vivo. As I mentioned before, the same has been true for basically every other antibody being developed (monoclonals and ones isolated from patients), which were also initially published in Nature/Science/etc with only in vitro and structural data.

There are multiple aspects that are novel here: their size, the trimer (rather than a cocktail), and their stability/delivery. All of these seem worthy of reporting. They say they're about to start clinical trials to see if they could be efficacious; they don't say that they will.

j / k navigate · click thread line to collapse