not vertically at least. the memory usage for indexing has room for improvement.
If I read the pprofs correctly, every scrape interval and every remote write allocates huge amounts of memory which is only cleaned up on garbage collection. You can easily need >64 gb ram for tenthousands of time series, otherwise you oom.
Biggest single promethueus server I have access to currently uses almost 64GiB of RAM and ingests about 80000 samples per second. Most of scrape intervals is 60s.
It is about 5 000 000 time series.
Note that we do have more time series - above server is just a horizontal shard, ingesting just one part of total metrics volume there.
