$300 or whatever it is is a lot, but in the USA it's a rounding error compared to the cost of healthcare for a problem like RSI, and in Europe it's a rounding error for a business compared to the cost of an employee unable to work, or suing because they were not given appropriate (i.e. ergonomic) tools. A DIY version (solder it yourself) is half the cost, but insurance/employer won't buy that.
For others, it's a tool they use for many hours every day. I spent €10 on my kitchen knives, and my friend who is a professional chef is appalled, but I wouldn't want to use his €200 laptop every day.
They're probably only going to sell a few thousand, so there isn't the economy of scale that makes something like a Microsoft Sculpt $100. Finally, it's made from individual components (key switches), so should be easily repairable if a single key should fail, but also took a lot more time to assemble. It ought to last many years.