Trying chrome now.
GitHub is the only mainstream site I've seen handle Ajax "properly".
I guess that's because most browsers used by people out there today do not have support for direct url path changing without causing a reload. It's only been possible since the introduction of the HTML5 History API, which solved that very problem. Unfortunately, it's only supported by the newer browsers.
In that case, the main benefit over a "regular" load is that javascript files that you use don't get to be evaluated over and over, ie you load them once for all.
On my machine, this alone saves 300ms per page.
On incompatible browsers the javascript functionality did not activate and clicking on the links led to the full versions of the page.
Maybe this library can save me some headache.